5 best HIPAA compliance software platforms for 2025

Healthcare deals stall when prospects ask for proof of Health Insurance Portability and Accountability Act (HIPAA) compliance and your team scrambles to gather screenshots and documentation. For founders and technical leaders at growing companies, manual compliance work pulls focus from building product and closing revenue. Every security questionnaire becomes a time sink, and the gap between your actual security posture and what you can prove creates friction in sales cycles.

Annual compliance audits no longer match how healthcare technology operates. Cloud adoption and digital health expansion have multiplied the ways Protected Health Information (PHI) can be exposed, with 725 breaches exposing 275 million records in 2024 alone. Buyers now expect continuous visibility into your compliance status, not point-in-time snapshots. And if enterprise healthcare customers require Health Information Trust Alliance (HITRUST) certification, the path from basic HIPAA compliance becomes even more complex without the right foundation.

This guide reviews the 5 leading HIPAA compliance platforms for 2025, comparing their automation depth, HIPAA Security Rule coverage, and pathways to related certifications like HITRUST. You will find detailed evaluation criteria, feature comparisons, and guidance on selecting the platform that fits your compliance needs and growth trajectory.

Top 5 HIPAA compliance software solutions

The state of HIPAA compliance software in 2025

HIPAA compliance software automates the work of protecting patient health data and proving you meet federal requirements. These platforms connect to your cloud systems, collect evidence automatically, and keep you audit-ready year-round.

Healthcare organizations and Business Associates—tech companies that handle patient data—face growing pressure to prove their security, with breach costs averaging $7.42 million in healthcare. Digital health expansion and cloud adoption have increased the ways PHI can be exposed.

The market has shifted in 3 key ways:

How we evaluated these HIPAA compliance tools

We assessed platforms on their ability to automate HIPAA workflows, integrate with healthcare tech stacks, and support pathways to related certifications. Our criteria weighted automation depth, HIPAA Security Rule coverage, and multi-framework efficiency.

Automated evidence collection
Manual screenshot gathering drains your team's time and creates gaps in documentation.
What percentage of HIPAA requirements can you automatically collect evidence for?



and real-time visibility
You cannot afford to discover compliance gaps during an audit when PHI is at risk—
for HIPAA audits or Office for Civil Rights (OCR) investigations.
How frequently does your platform scan for compliance drift?


Policy automation and management
Creating HIPAA-compliant policies from scratch is time-consuming and error-prone.
Do you provide HIPAA-specific policy templates out of the box?


Integration depth and breadth
Without deep integrations, you will be stuck with manual processes that do not scale.
How many integrations do you offer for healthcare organizations?






HIPAA Security Rule coverage
Incomplete coverage means you need additional tools or manual processes to fill gaps.
How many HIPAA controls does your platform cover?


Business Associate vs. Covered Entity support
Your obligations differ significantly based on your role in the healthcare ecosystem.
Does your platform differentiate between Business Associate and Covered Entity requirements?


PHI-specific risk management
Protected Health Information requires specialized risk assessment approaches.
How does your platform help map PHI data flows across our systems?


Breach notification readiness
HIPAA's 72-hour breach notification requirement demands prepared processes and documentation.
What breach response templates and workflows do you provide?






Audit preparation and readiness
Streamlined audit prep reduces time spent gathering evidence and maintains continuous readiness.
What is the typical timeline from implementation to audit-readiness?


HITRUST pathway and integration
Many healthcare enterprises require HITRUST certification, which builds on HIPAA—certified organizations achieve
.
Do you offer direct integration with HITRUST MyCSF?


Auditor collaboration features
Efficient auditor access reduces back-and-forth communication and accelerates completion.
Do you provide an auditor portal for evidence sharing?






Cross-framework control mapping
Most organizations need multiple frameworks beyond HIPAA, creating duplicate work without mapping.
What percentage of HIPAA controls overlap with SOC 2 and ISO 27001?


Framework scalability
Your compliance needs grow as your business expands into new markets and customer segments.
How easy is it to add additional frameworks after implementing HIPAA?






Trust Center and proof of compliance
Healthcare customers need instant access to your compliance documentation to accelerate deals.
Do you offer a Trust Center where we can publicly share our compliance status?


Security questionnaire automation
Healthcare
are lengthy and repetitive, slowing down sales cycles.
What is your AI answer acceptance rate for questionnaire responses?

5 best HIPAA compliance software platforms reviewed

Each platform below is assessed on its automation capabilities, HIPAA Security Rule coverage, and ability to provide a pathway to HITRUST certification.

1. Vanta

Vanta is an AI-powered Trust Management Platform that automates HIPAA compliance alongside SOC 2, ISO 27001, and HITRUST. Vanta connects to your cloud infrastructure, access controls, and security tools through hundreds of integrations to collect evidence automatically.

Vanta maps HIPAA controls to related frameworks, eliminating duplicate evidence collection when you need multiple certifications. As the only certified HITRUST reseller with direct MyCSF integration, Vanta provides the most efficient pathway from HIPAA to HITRUST. The Trust Center and AI-powered Questionnaire Automation prove compliance to customers and deflect security reviews before they reach your team.

Ideal for: Healthcare technology companies and Business Associates that need HIPAA compliance alongside SOC 2 or ISO 27001, with a clear pathway to HITRUST certification.

Pros
Cons





Direct MyCSF integration provides the most efficient path from HIPAA to HITRUST certification.

Focuses on Security and Breach Notification Rules, less suitable for Covered Entities needing full Privacy Rule support.



Real-time monitoring surfaces gaps before they become audit problems or security incidents.

Deep integrations require initial configuration effort to connect all relevant systems.



Self-service compliance documentation deflects up to 87% of security reviews.

Complex multi-entity structures should evaluate workspace configuration during implementation.

2. Secureframe

Secureframe is an automated compliance platform supporting HIPAA, SOC 2, and federal frameworks like the Federal Risk and Authorization Management Program (FedRAMP). The platform provides integrations for evidence collection, pre-built policy templates, and AI features for risk scoring.

Secureframe automates core compliance tasks but lacks a direct HITRUST partnership or MyCSF integration. Support is limited to 24/5 chat and US-based customer success managers. Customers have reported price increases at renewal.

Ideal for: Organizations seeking an entry-level compliance solution for common frameworks that prioritize initial price over advanced automation or HITRUST pathway.

Pros
Cons





Often priced lower than market leaders for early-stage companies.

Lacks HITRUST partnership and MyCSF integration, creating manual work for certification.



Offers dedicated support for FedRAMP and Cybersecurity Maturity Model Certification (CMMC) compliance.

Support limited to 24/5 chat and US-based customer success managers.



Often bundles software with audit services from partners.

Customers note need for manual support, suggesting less comprehensive automation.

3. Sprinto

Sprinto is a compliance automation platform targeting startups and small companies with low-cost entry pricing. The platform automates evidence collection for SOC 2, ISO 27001, and HIPAA, offering a free Trust Center and limited security questionnaire automation.

Sprinto's focus on low cost comes with trade-offs in product depth and scalability. The platform has shallower integrations and weaker automation. It lacks support for advanced frameworks like HITRUST and Payment Card Industry (PCI).

Ideal for: Price-sensitive startups needing basic compliance for SOC 2 or HIPAA without immediate plans for scaling to complex standards.

Pros
Cons





Aggressive discounting makes it one of the cheapest options for getting started.

Does not support HITRUST, PCI, or key AI frameworks.



Generally easy to navigate for basic compliance tasks.

Weaker integrations require more manual effort, increasing total cost of ownership.



Designed for quick setup for common frameworks.

Struggles to support growing companies with custom integrations or multi-framework needs.

4. Drata

Drata is a compliance automation platform offering strong continuous monitoring and evidence collection for SOC 2, ISO 27001, and HIPAA. The platform features a Trust Center that allows for evidence sharing and AI-powered automation for policy generation and security questionnaires.

Drata's primary weakness in healthcare is its lack of a direct HITRUST partnership and MyCSF integration. While it supports the HIPAA framework, the pathway to HITRUST certification is less streamlined than Vanta.

Ideal for: Organizations needing multi-framework compliance automation with a focus on building customer trust through a public-facing security portal.

Pros
Cons





Performs daily evidence collection and control monitoring.

Lacks certified partnership or MyCSF integration for efficient HITRUST certification.



SafeBase acquisition provides feature-rich portal for sharing compliance documentation.

Supports HIPAA but lacks deep healthcare-specific focus and partnerships.



Provides solid automation across wide range of security and privacy frameworks.

Competes closely with Vanta on core features but lacks key healthcare differentiator.

5. OneTrust

OneTrust is a comprehensive enterprise Governance, Risk, and Compliance (GRC) platform covering privacy, security, and governance. With a large customer base including many Fortune 100 companies, it is known for deep privacy management capabilities.

Its compliance automation product is a newer addition built from acquired technology. Customers report it is less automated and harder to implement than focused solutions. The platform's complexity can be overkill for agile healthcare tech companies needing fast, continuous HIPAA compliance.

Ideal for: Large, mature enterprises with complex privacy requirements needing a single platform to manage broad GRC programs.

Pros
Cons





Market leader in privacy management for complex global data privacy needs.

Customers migrate to Vanta for more automated evidence collection and better experience.



Can serve as single source of truth for security, privacy, and governance.

Platform breadth and legacy architecture make it slow and difficult to implement.



Widely adopted by large enterprises, making it familiar choice for established GRC teams.

Complexity often unnecessary for agile tech companies needing fast, focused compliance.

How to choose the right HIPAA compliance software

Follow these steps to select the platform that fits your organization's needs and growth trajectory.

Build continuous HIPAA compliance with the right platform

HIPAA compliance is an ongoing commitment to protecting health information, not a one-time project. The right platform transforms this from a manual burden into an automated process that builds trust and accelerates growth.

Vanta unifies HIPAA compliance with related frameworks, surfaces security gaps before they become audit problems, and helps you prove your security posture through its Trust Center and Questionnaire Automation. Request a demo to see how Vanta provides the proven path from HIPAA to HITRUST.

Frequently asked questions

What is the difference between HIPAA compliance software and HIPAA-compliant software?

HIPAA compliance software helps your organization achieve and maintain compliance through automation, monitoring, and evidence collection. HIPAA-compliant software is any tool, like an encrypted messaging app, that is already built to meet HIPAA requirements for handling PHI.

Does HIPAA compliance software work for both Business Associates and Covered Entities?

Most platforms support both, but their focus differs for Business Associates. Automation platforms excel at Security Rule requirements critical for Business Associates. Covered Entities like hospitals must also address extensive Privacy Rule obligations, which may require additional specialized tools.

How does HIPAA compliance software support HITRUST certification?

HIPAA controls have significant overlap with HITRUST requirements, so platforms with cross-framework mapping let you leverage HIPAA evidence toward HITRUST. Leading platforms like Vanta accelerate this further by offering direct integration with the HITRUST MyCSF portal.

Can HIPAA compliance software automate evidence collection for audits?

Yes, leading platforms automate evidence collection by integrating directly with your cloud infrastructure, identity systems, and security tools. This continuous process replaces manual screenshot gathering and ensures your organization is always prepared for an audit.